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Seractide Specifications
Other name: AC TH (1-39)
CAS: 12279-41-3
MF: C207H308N56O58S1
MW: 4541.07
EINECS: 634-154-0
Purity: 99%
Seractide Description
ACTH, also known as corticotropin, is a cleavage product from a larger precursor proopiomelanocortin (POMC). This 39 amino acid-peptide hormone is produced in the anterior pituitary gland upon stimulation by the corticotropin releasing hormone from the hypothalamus in response to stress. It stimulates the secretion of steroid hormone, specifically glucocorticoids in the adrenal cortex by acting through a cell membrane receptor (AC TH-R). In mammals, the action of ACTH is limited to those areas of the adrenal cortex in which the glucocorticoid hormones cortisol and corticosterone are formed. AC TH has little control over the secretion of aldosterone, the other major steroid hormone from the adrenal cortex. Seractide is potent endogenous melanocortin receptor 2 (MC ) agonist (EC=57 pM). Component of the hypothalamic-pituitary-adrenal (HPA) axis that stimulates glucocorticoid production and release from the adrenal cortex. Induces insulin resistance, promotes a proinflammatory profile and stimulates UCP-1 in adipocytes in vitro.
Seractide Application
As adjunctive therapy of Rheumatic Disorders for short-term administration, to tide the patient over an acute episode or exacerbation. During an exacerbation of Collagen Diseases as maintenance therapy. Control of severe or incapacitating allergic conditions, Pemphigus, bullous dermatitis herpetiformis.
