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Melanotan 1 Specifications
Other name: MelanotanⅠ, Melanotan-1, MT1, MT-1
CAS No. 75921-69-6
MF: C78H111N21O19
MW: 1646.845
Purity 99% min
Melanotan 1 Description
Melanotan 1 is a synthetic analogue of alpha-melanotocyte stimulating hormone. It is used clinically, in Europe, to prevent sun-related skin damage (i.e. phototoxicity) from occurring in people suffering from erythropoietic protoporphyria. Though initially developed as a sunless tanning agent, melanotan 1 has been found to have a number of physiologic effects on blood pressure, feeding behavior, central nervous system function, and more. The peptide is in phase 3 clinical trials for the treatment of polymorphose light eruption and is in phase 2 clinical trials for the treatment of actinic keratosis (a specific type of skin damage caused by the sun) and its more serious counterpart, squamous cell carcinoma.
Melanotan 1 is similar to naturally occurring alpha melanocyte stimulating hormone alpha-MSH (Melanotan 2). Alpha-MSH is known for its influence on melanocytes, the cells in skin and hair responsible for pigmentation. This function is mediated via strong binding to melanocortin receptor 1. Alpha-MSH is a non-selective full agonist of melanocortin receptors 1, 3, 4, and 5. Melanotan 1 differs from alpha-MSH (Melanotan 2) by a single amino acid and was actually first developed as a sunless tanning agent. Research into melanocortin receptors and their effects, scientists quickly discovered that while melanotan 1 did indeed cause pigmentation, and altered baseline metabolism. Subsequent study of melanotan 1 and other melanocortin-binding proteins helped scientists to better understand the melanocortin signaling system.
Melanotan 1 VS Melanotan 2
Both Melanotan-1 and Melanotan 2 are analogs of the peptide hormone alpha-melanocyte stimulating hormone (α-MSH) that tend to induce skin tanning. Unlike Melanotan 1, Melanotan 2 has been shown to have aphrodisiac properties, the additional effect of increasing libido. Melanotan-1 is a non selective agonist of the melanocortin receptors (MC1R,MC3-5R). As an analogue of α-MSH, its mechanism of action is biomimicry of the natural mammalian tanning process.
Melanotan 1 Application
Melanotan 1 (MT-1), a synthetic peptide, has garnered attention not only for its primary function of inducing skin pigmentation but also for its potential ancillary benefits. As a derivative of the naturally occurring alpha-melanocyte-stimulating hormone (α-MSH), MT-1 engages melanocortin receptors, regulating melanin production in the skin. While its primary use is to provide a tan-like appearance without exposure to harmful UV rays, users have reported additional effects on mood, libido, and appetite. Applications as follows:
Primary Function: Skin Pigmentation
Ancillary Benefits: Mood Enhancement
Ancillary Benefits: Increased Libido
Ancillary Benefits: Appetite Suppression
Melanotan 1 Recommended Dosage
MT-1 loading Step: 0.5 ~ 2mg are injected subcutaneously daily, and normally about 7 to 10 days
MT1 maintenance Step: 0.5mg taken twice per week
Attention: If tan is getting lighter, MT1 dosage might be increased, also could short the period between injections. If getting to dark, MT1 dosage should be lowered, or the injection frequency decreased.
