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MK-677 Specifications
Other Name: Ibutamoren, Nutrobal
CAS No.: 159752-10-0
MF: C28H40N4O8S2
MW: 624.77
Appearance: White crystalline powder
Purity: 99%
MK-677 Description
MK-677 (also known as ibutamoren mesylate), promotes the secretion of the growth hormone (GH) and increases insulin-like growth factor 1 (IGF-1) (R, R).
MK-677 increases growth hormone levels, by mimicking the action of the hormone ghrelin (R), and binding to one of the ghrelin receptors (GHSR) in the brain (R). Activated GHSR stimulates growth hormone release from the brain.
GHSR is found in brain regions that control appetite, pleasure, mood, biological rhythms, memory, and cognition (R). Therefore, we can expect that ibutamoren may also affect these functions. However, so far, clinical studies describe only the effects ibutamoren has on appetite, and as expected, like ghrelin, ibutamoren increases it.
A great thing about MK-677 is that it increases growth hormone levels with little or no increase in other hormones, such as cortisol (R, R). Cortisol suppresses the immune system, reduces wound healing, and impairs learning and memory, and it’s usually not good to have this hormone elevated.
MK-677 Observable Effects
1. Injury Repair:
Injury repair is seen with Ibutamoren Nutrobal (MK677) as well. Try stacking it with N2jointrx and TS Krill Oil from N2bm and you will notice a tremendous difference in how your joints and soft tissues feel.
2. Muscle Gains & Fat loss:
Ibutamoren Nutrobal (MK677) is great for those who are bulking since it increases appetite so much, allowing you to up your macros and get bigger and stronger. It also can be used to cut down body fat since it alters how our body metabolizes food.
3. Strength Gains:
Those who weight train will love the faster recovery between workouts. They also are impressed by the lean muscle mass gains and the mild strength gains they get.
4. Increases Bone Density
Growth GH hormone increases bone turnover and eventually bone density . However, because of the increased turnover in subjects treated with growth GH hormone, bone density can initially decrease before increasing . Basically, it takes time (> 1 year) to see the bone density increase.
In healthy obese male volunteers, ibutamoren increased bone turnover. In elderly adults, ibutamoren increased bone building, as measured by osteocalcin, a marker of bone turnover. In post-menopausal women, ibutamoren increased bone mineral density, which helps increase bone strength and prevent osteoporosis.
MK-677 Dosage
Results have been shown from doses between 5-25mgs a day, dose dependent results should be expected. Higher doses, over 50mgs, have been reported by some, but no need to overdo it.
MK-677 Side-effects
The most frequent side effects of ibutamoren are an increase in appetite and transient, mild lower extremity edema and muscle pain.
Several studies report an increase in fasting blood glucose and a decrease in insulin sensitivity.
These side effects are similar to those observed in people with elevated growth hormone levels, mainly joint pain and insulin resistance.
Although most studies report little or no side effects, one study was terminated because of serious adverse events. In elderly patients with hip fracture, ibutamoren elevated blood pressure, blood glucose and HbA1c, and there were cases of congestive heart failure. The patients experiencing congestive heart failure were over 80 and had a history of prior heart failure.
It would be prudent to watch your carbohydrate intake and regularly check blood sugar and insulin levels while taking ibutamoren.
As an anabolic, ibutamoren should be avoided if you have cancer. Both growth hormone and IGF-1 may promote cancer growth.
