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L-Triiodothyronine Specifications
Other name: T3, Cytomel
CAS No. 6893-02-3
M.F. C15H12I3NO4
M.W. 650.9735
Purity: 99%
Appearance: White powder
T3 Certificate of Analysis
| Items of analysis | Specification | Results |
| Appearance | Light yellow to buff-colored | Conforms |
| Specific rotation | +23.0° C=2，in ethanol or 0.1N HCl | +23° |
| Loss on Drying | <4.0％ | 3% |
| Lodides content | <0.08％ | <0.08％ |
| Chloride content | 1.20% | 0.002 |
| Grain size(meshes) | 60-80 | Conforms |
| PH of saturated solution | 8.5~9.5 | 9 |
| Liothyronine | >95.0％ and <101.0% | 0.99 |
| Levothyroxine | <5.0％ | 0.01 |
| Conclusion | Conforms to Enterprise Standard |
L-Triiodothyronine/T3 Effects
M-T3 increases the basal metabolic rate and, thus, increases the body’s oxygen and energy consumption. The basal metabolic rate is the minimal caloric requirement needed to sustain life in a resting individual. T3 acts on the majority of tissues within the body, with a few exceptions including the spleen and testis. It increases the production of the Na+/K+ -ATPase (which normally constitutes a substantial fraction of total cellular ATP expenditure) without disrupting transmembrane ion balance and, in general, increases the turnover of different endogenous macromolecules by increasing their synthesis and degradation.
(1) T3 stimulates the production of RNA Polymerase I and II and, therefore, increases the rate of protein synthesis. It also increases the rate of protein degradation, and, in excess, the rate of protein degradation exceeds the rate of protein synthesis. In such situations, the body may go into negative ion balance.
(2) T3 potentiates the effects of the β-adrenergic receptors on the metabolism of glucose. Therefore, it increases the rate of glycogen breakdown and glucose synthesis in gluconeogenesis.
(3) T3 stimulates the breakdown of cholesterol and increases the number of LDL receptors, thereby increasing the rate of lipolysis.8 weeks/2 months. This period is long enough to gain maximum benefits.
T3 vs T4
T3 is the true hormone. Its effects on target tissues are roughly four times more potent than those of T4. Of the thyroid hormone that is produced, just about 20% is T3, whereas 80% is produced as T4. Roughly 85% of the circulating T3 is later formed in the liver and anterior pituitary by removal of the iodine atom from the carbon atom number five of the outer ring of T4. In any case, the concentration of T3 in the human blood plasma is about one-fortieth that of T4. The half-life of T3 is about 2.5 days. The half-life of T4 is about 6.5 days.
