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LL-37 Specifications
Other name: Cathelicidin, CAP-18
CAS: 597562-32-8
MF: C205H341N61O52
MW: 4492.27854
EINECS: 200-001-8
Purity: 99%
LL-37 Description
LL-37 is the only known human cathelicidin, which is a large protein family with diverse function. These peptides, which are primarily found in macrophages and polymorphonuclear leukocytes (both types of white blood cell), are important for killing bacteria, but have been found to have other dramatic effects as well. The entire class is often referred to as antimicrobial peptides (AMPs). LL-37 has been found to play important roles in autoimmune disease, cancer, and wound healing.
LL-37 Application
LL-37, while primarily billed as an antimicrobial peptide, actually plays a role in a number of inflammatory diseases such as psoriasis, lupus, rheumatoid arthritis, and atherosclerosis. Depending on the local inflammatory environment and the particular cells involved, LL-37 has several different immune system modulating behaviors. It has been found to:
Decrease keratinocyte apoptosis
Increase IFN-alpha production
Alter chemotaxis of neutrophils and eosinophils
Down-regulate signaling through toll-like receptor 4 (TLR4)
Increase IL-18 production
Decrease levels of atherosclerotic plaques
