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FOX04-DRI Specifications
CAS No.: 2460055-10-9
Purity: 99%
Appearance: White powder
FOX04-DRI Description
FOX04-DRI (Retro-Inverso) is a synthetic, slightly modified version of the standard FOXO4 protein. The modification prolongs half-life of the protein and allows it to interfere with normal FOXO4 function. FOXO4-DRI has been shown in research to prevent normal FOXO4 binding to p53, thereby allowing for elimination of senescent cells, improved organ function, and younger tissue “biological age.” FOXO4-DRI impacts insulin signaling, cell cycle regulation, and oxidative stress signaling pathways. FOXO4-DRI is a cell penetrating peptide shown to selectively induce apoptosis of senescent cells thereby reversing effects of aging in animal studies.
FOX04-DRI Application
Potential applications for FOXO4-DRI could include skin rejuvenation by reducing the accumulation of age-related senescent cells. This mechanism could improve skin texture and elasticity, hallmarks of youthful skin. As with any emerging therapy, understanding the safety profile of FOXO4-DRI is paramount. Thus far, preclinical trials suggest it has promising potential with low toxicity, although further studies are essential before it becomes widely available for therapeutic use.
