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Clomifene Citrate Specifications
Other name: Clomid, Clomiphene Citrate
CAS NO: 50-41-9
Molecular Formula: C32H36ClNO8
Molecular Weight: 598.08
Melting point: 116.5-118C
Purity: 99%
Appearance: White powder
Clomifene Citrate Description
Clomiphene Citrateis a mixed estrogen agonist/antagonist (activator/blocker) which, when bound to the estrogen receptor, putsClomiphene Citratein a somewhat different conformation (shape) than does estradiol. The estrogen receptor requires binding of an estrogen or drug at its binding site and also the binding of any of several cofactors at different sites. As for women, the only real use for Clomiphene Citrate is the possible management of endogenous estrogen levels near contest time. This can increase fat loss and muscularity, particularly in female trouble areas such as this HIPS and thighs. Clomiphene Citrate however often produces troubling side effects in women (discussed below), and is likewise not in very high demand among this group of athletes. Clomid are also occasionally used periodically during a steroid cycle, in an effort to prevent natural testosterone levels from diminishing. In many instances this practice can prove difficult however, especially when using strong androgens for longer periods of time.
Clomid (clomiphene citrate) is a nonsteroidal, ovulatory stimulant used to treat ovulatory dysfunction and polycystic ovary syndrome in women who, after other reasons for pregnancy failure have been ruled out, desire pregnancy and follow additional instructions that make pregnancy more likely to occur with this drug use (see below about dosage and use). In addition, these women and their sperm donors usually need to undergo a number of tests scheduled by their OB-GYN doctor before this drug is started. The generic name for Clomid is clomiphene citrate. Common side effects of Clomid include abnormal vaginal bleeding, breast discomfort, headache, nausea, and vomiting. Contact your doctor if you experience serious side effects of Clomid including shortness of breath, seizures, stroke, or chest pain.
Clomifene Citrate Certificate of Analysis
| Results Of Analysis Tests |
| ITEM | SPECIFICATION | RESULT |
| Appearance | White or off-white powder | Conforms |
| Identification | UV conform | Conforms |
| Organic nitrogenous base | Conforms | Conforms |
| Citrate | Conforms | Conforms |
| Solution | Slightly soluble in water and in chloroform freely soluble in methanol sparingly soluble in alcohol insoluble in ether | Conforms |
| Water | Not more than 1.0% | 0.4% |
| Heavy metals | Not more than 0.002% | Conforms |
| Organic volatile impurities | Ethanol: Not more than 5000PPM | 800PPM |
| Related impurities | Related compound A ≤2.0% | 0.65% |
| Individual ≤0.5% | 0.38% |
| Total impurities ≤2.0% | 1.58% |
| (Z) isomer | 30% ~ 50% | 31% |
| Assay | 98.0% ~ 102.0% | 98.5% |
| Conclusion | The specification conforms with USP 36 standard |
Clomid Application
1. Ovulation induction: for the treatment of anovulatory or inadequate luteal malfunction; infertility women who hope for pregnancy. At the 3-5 days of menstrual bleeding or progesterone withdrawal bleeding, orally administrate 50 mg daily and continuously take for five days. Usually ovulation occurs at about 7 days after stopping drugs when having intercourse is easy to increase the pregnancy rate. If the dose can induce ovulation, the treatment can be repeated; if there is no ovulation, the daily dose can be increased to 100 ~ 150 mg with administration in twice upon an empty stomach for 5 consecutive days. At appropriate indications, most patients can ovulate in the first cycle of treatment, for patients of long-term amenorrhea; their endometrial is not sensitive enough which requires two to three cycles of treatment for induction menstruation.
If ovulation still doesn't occur after three cycles, people should be reconsidered whether the diagnosis is correct.
2. Functional uterine bleeding, secondary amenorrhea or severe oligomenorrhea, and polycystic ovary syndrome: for people who ha menstruation, they should begin to take drug at the 5th day of menstrual; People without menstruation may start at any day or at the 5th day of the in artificial cycle with 1/d 50 ~ 100mg.
3. Male with low sperm and infertility: 25mg /d/per time; consecutively take for 25 days as one treatment course. Repeat it after stopping for five days until the sperm count reach normal standards; this process normally takes 3 to 12 courses. Male patients with no sperm should not apply clomiphene citrate for therapy.
4. Senile vaginitis and non-specific vaginitis: apply one tablets of clomiphene citrate per day; place it with vaginal suppositories (each tablets contains clomiphene 0.1 mg and chloramphenicol 250 mg) into the vagina with a week being a course; It is reported that it has better efficiency than chlorhexidine suppository.
5. Treatment of the anus, vulva, scrotum itching and eczema, dermatitis, chilblains, scabies; can apply 10% clomiphene citrate cream for treating affected area with a rapid efficacy, a long duration and high safety.
Clomid Recommended Dosage
If you're going to put it into your body from medicine to hormones or in this case a SERM you are going to want to know the proper dose; after all, without this information it's unlikely you're going to be able to use it correctly. Like many things a Clomid dosage can vary quite dramatically but one thing is for certain the average Clomid dosage among many performance enhancers is far too low. It is very common to see a Clomid dosage of 50mg per day for Post Cycle therapy (PCT) purposes and while there is a use for this dose during PCT it should be noted, 50mg of this SERM is about the equivalent of 10mg of Nolvadex.
