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Anastrozole Specifications
Other name: Arimidex
CAS No.: 120511-73-1
MF: C17H11N5
MW: 285.30
Purity: 99.77%
Appearance: White powder
Anastrozole Description
Anastrozole is a nonsteroidal aromatase inhibitor that works to inhibit the conversion of testosterone and other steroid hormones into estrogen. It is used primarily in the prevention and treatment of various types of breast cancer in women, as well as in the treatment of gynecological disorders that are estrogen-related in nature. Unlike many other anti-estrogens, Anastrozole targets a specific enzyme that transforms the androgenic hormone testosterone into estrogen, meaning that it doesn't affect other important sex hormones. For this reason, Anastrozole is rapidly gaining popularity among bodybuilders and athletes for use in PCT (post-cycle therapy) to reduce the negative effects caused by excess estrogen.
Anastrozole Certifcate of Analysis
| Results Of Analysis Tests |
| Item | Specifications | Results |
| Description | White or off-white crystalline powder | Conform |
| Solubility | Freely soluble in methanol, ethanol, acetonitrile, ethylacetate and chloroform, slightly soluble in water and 0.1M hydrochloric acid solution | Conform |
| Identification | IR Reactive | Conform with standard IRConform |
| Melting point | 82.0 ~ 85.0℃ | 83.1 ~ 83.3℃ |
| Related substances Impurity B Impurity CImpurity DImpurity ESingle Unknown ImpurityTotal Unknown ImpurityTotal Impurity | Not more than 0.2%Not more than 0.2%Not more than 0.1%Not more than 0.1%Not more than 0.1%Not more than 0.2%Not more than 0.5% | 0.02%0.03%0.02%0.03%0.04%0.08%0.23% |
| Residual solventDichloromethanChloroformEthanol CyclohexaneEthylacetate | Not more than 0.06%Not more than 0.006%Not more than 0.5%Not more than 0.08%Not more than 0.5% | Not detectedNot detected0.04%0.02%0.1% |
| Residue on ignition | Not more than 0.1% | 0.03% |
| Water | Not more than 0.3% | 0.08% |
| Heavy metals | Not more than 0.001% | <0.001% |
| Assay(on dry basis) | 98%~102%(HPLC) | 99.77% |
| Conclusion | The specification conforms with UPS40 standard |
Anastrozole Usages
Usage In Men
Anastrozole has been tested for reducing estrogens, including estradiol, in men. Excess estradiol in men can cause benign prostatic hyperplasia, gynecomastia, and symptoms of hypogonadism. It can also contribute to increased risk of stroke, heart attack, chronic inflammation, prostate enlargement and prostate cancer.Some athletes and body builders will also use anastrozole as a part of their steroid cycle to reduce and prevent symptoms of excess estrogens; gynecomastia and water retention. Study data suggests dosages of 0.5 mg to 1 mg a day reduce serum estradiol approx. 50% in men, which differs in postmenopausal women.
Usage In Children
Anastrozole may be used off-label in children with precocious puberty, or children with pubertal gynecomastia. Following the onset of puberty, the epiphyseal plate begins to close due to an increased amount of estrogen production escaping local metabolism and spreading to the circulatory system. It is shown to help slow this process, and increase adult height prediction in adolescent males treated with protein-based peptide hormones for the treatment of growth hormone deficiency.
