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Acadesine Specifications
Other name: AICAR
CAS: 2627-69-2
Molecular Formula: C9H14N4O5
Molecular Weight: 258.23
EINECS: 220-097-5
Melting point : 214-215 °C
Appearance: White or Off-White Powder .
AICAR Certificate of Analysis
| Item | Specification | Result |
| Appearance | White powder | White powder |
| Related substance (HPLC) | Total impurity ≤0.5% | 0.20% |
| Max single impurity ≤0.1% | 0.06% |
| Odor | Characteristic | Complies |
| Assay | 99% | 99.80% |
| Sieve analysis | 100% pass 80 mesh | Complies |
| Loss on Drying | ≤1.0% | 0.12% |
| Residue on Ignition | ≤1.0% | 0.09% |
| Heavy Metal | <10ppm | Complies |
| As | <0.1ppm | 0.05ppm |
| Pb | <0.1ppm | 0.05ppm |
| Cd | <0.1ppm | 0.05ppm |
| Residual Solvents | <100ppm | Complies |
| Residual Pesticide | Negative | Complies |
| Total Plate Count | <1000cfu/g | Complies |
| Yeast & Mold | <100cfu/g | Complies |
| E.Coli | Negative | Complies |
| Salmonella | Negative | Complies |
Function of AICAR transformylase
AICAR transformylase, also known as AICARFT (AICAR transformylase/IMP cyclohydrolase), is an enzyme involved in the purine biosynthesis pathway. It plays a crucial role in converting 5-Aminoimidazole-4-carboxamide ribonucleotide (AICAR) to Inosine monophosphate (IMP), an essential precursor for the synthesis of purine nucleotides.
AICAR transformylase catalyzes the addition of a formyl group to AICAR, resulting in the formation of N-formyl-AICAR (NFAICAR). This step is important for the subsequent reactions in the pathway.
After the transformylation step, AICAR transformylase also possesses cyclohydrolase activity. It converts NFAICAR into IMP by removing the formyl group and rearranging the molecule.
The production of IMP is a critical step in the purine biosynthesis pathway, as it serves as a precursor for the synthesis of adenine and guanine nucleotides, which are essential components of DNA, RNA, and ATP (adenosine triphosphate).
Deficiencies or dysfunctions in AICAR transformylase can lead to metabolic disorders, specifically in the purine metabolism pathway, resulting in diseases such as AICAR transformylase/IMP cyclohydrolase deficiency (ATIC deficiency). These conditions are characterized by abnormalities in the levels of purine nucleotides, leading to neurological symptoms and developmental delays.
Mechanism of action of AICAR (Acadesine)
The mechanism of action of AICAR (5-Aminoimidazole-4-carboxamide ribonucleotide) primarily involves activation of the enzyme AMP-activated protein kinase (AMPK).
AICAR is taken up by cells and converted into its active form, ZMP (5-Aminoimidazole-4-carboxamide ribonucleotide monophosphate). ZMP mimics the effects of AMP (adenosine monophosphate), a cellular energy sensor, and allosterically activates AMPK.
Once activated, AMPK phosphorylates various downstream targets, leading to a wide range of metabolic effects. It acts as a master regulator of cellular energy homeostasis and helps maintain energy balance.
AICAR (Acadesine) Dosage
Dosages range from 150 miligrams (mg) per day (if stacked with GW), up to 500mg a day when used solo. Considering thefact that each bottle typically comes in 50mg dosages, that is quite expensive, as already mentioned above, Economically, itmakes most sense to run AlCAR during the 4 weeks leading up to your competition.
